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Equip yourself with skills to implement in your clinic or research group. Improve your statistical understanding and interpretation of clinical trials and research in RA.

Develop a comprehensive understanding of statistical methods and analyses. Hear from experts across the globe for 2 days of scientific discussion. Learn about themes, from translational research roundtables to the power of meeting facilitation in everyday clinical practice.

Understand how to collaborate with PAGs and what is most important for patients. Listen to an eclectic host of external experts in the RTA podcast series.

Find out about topical themes including clinical controversies in RA and the role of digital medicine in the future management of RA.

All applications are judged against these criteria by the independent steering committee. He founded Emeritus Research in , which has coordinated and conducted over clinical trials to date.

During his scientific career, he has participated in multiple funded research projects and has published more than scientific articles in international journals, as well as being a board member of both the research unit of Hospital Universitario La Paz and the Spanish Society of Rheumatology SER.

He has authored more than peer-reviewed articles, reviews and book chapters. Dr Spinelli is involved in clinical and experimental investigations into autoimmune rheumatic diseases focusing on the role of post-translational modifications and autoantibodies in rheumatoid arthritis, lupus and cardiovascular comorbidity in rheumatic diseases.

Her clinical activity is also focused on rheumatoid arthritis and systemic lupus erythematosus; in collaboration with Prof Fabrizio Conti, she opened the Lupus Clinic Roma Sapienza and Arthritis Center Roma Sapienza, both university outpatient clinics.

He has published over peer-reviewed manuscripts. She is the Division Head in Rheumatology at St. Her research includes epidemiologic studies in scleroderma, systemic lupus erythematosus and rheumatoid arthritis, including outcome measurements, clinical trials and disease manifestations.

Dr Pope has published over peer-reviewed articles, 11 chapters, abstracts and several Cochrane meta-analysis reviews.

She has mentored more than students and trainees. His major interest is in translational research, focusing on innate immunity and cytokine signalling in rheumatic diseases.

Currently, he is investigating the possibility of JAK inhibitors in non-RA diseases and working on novel pathways that relate to the disease activity of RA.

Any abnormal rise or fall in the platelet cell count can cause noticeable symptoms in some people. In other cases, the person may not experience any symptoms at all and will only learn of the abnormal levels if blood tests are performed for other reasons.

Mild to moderate thrombocytosis is common with rheumatoid arthritis. Symptoms are usually mild to non-existent. It is rare for RA-associated thrombocytosis to cause severe complications.

The one exception may be in older adults with cardiovascular disease in whom chronic thrombocytopenia may increase the risk of a stroke or heart attack.

Note, however, that long-term RA in and of itself increases cardiovascular risk. In people with RA, thrombocytopenia may be mild and cause few signs or symptoms.

If the platelet count drops beneath a certain threshold, the inability to clot will manifest with increasingly obvious symptoms.

In rare cases, the platelets may be so low that internal bleeding occurs. Common signs and symptoms of thrombocytopenia include:.

Platelet disorders are primarily diagnosed with a complete blood count CBC. This is a blood test that assesses the overall composition of your blood as well as its individual components, including your platelets.

While the CBC can provide definitive evidence of a platelet abnormality, your doctor may also perform blood tests known as erythrocyte sedimentation rate ESR and C-reactive protein CRP to measure the level of generalized inflammation in your body.

Your doctor may explore other possible causes if your symptoms are unusual or severe. Depending on the suspected cause, the investigation may include a bone marrow biopsy , imaging tests, blood tests, or a blood culture.

The differential diagnoses for thrombocytosis may include:. The differential diagnoses for thrombocytopenia may include:.

The treatment of platelet disorders in people with rheumatoid arthritis can vary depending on the underlying cause. Thrombocytosis in people with RA typically requires no treatment and will usually improve once the underlying inflammation is controlled.

The medication options include those that directly reduce inflammation and others that temper the autoimmune response. Effort should also be made to quit smoking , exercise regularly , and lose excess weight , all of which can reduce inflammation and keep your RA symptoms under control.

Immune thrombocytopenia also tends to improve once the autoimmune response is brought under control. Corticosteroids like prednisone may be used to support therapy by directly reducing inflammation.

NSAIDs may also be prescribed but are generally avoided in people with low platelet counts due to increased risk of bleeding.

If your platelet count doesn't recover with treatment or is especially severe, your doctor may recommend intravenous immunoglobulin IVIG.

Immunoglobulin is another type of antibody that your body normally makes to fight off infections. With IVIG, immunoglobulin purified from the blood of healthy donors is delivered through an IV drip, usually for several hours a day for one to five days.

The advantage of IVIG is that it can raise your platelet count quickly, albeit temporarily. If your RA medications are causing a drop in your platelet count, your doctor may recommend a reduction in your dose.

The drugs most commonly associated with this are:. If the symptoms are especially severe or platelet levels fail to recover with a dose reduction, your doctor may stop treatment and switch you to another drug.

The anti-CCP test is similar to the rheumatoid factor antibody test, which features later on in this article. However, doctors often use it in preference to the rheumatoid factor test for greater accuracy.

What it tests : This tests detects the presence of CRP, which the liver produces in response to inflammation in the body.

Interpreting the results : The presence of CRP can indicate inflammation anywhere in the body, but certain medical conditions, such as obesity and infection, can also increase CRP in the blood.

What it tests : This test lasts for 1 hour, and it measures the speed at which the red blood cells in a sample of blood settle at the bottom of a test tube.

Interpreting the results : Elevated ESR results can indicate inflammation in the body. However, some other conditions, such as anemia and infection, can also cause an elevated ESR.

Interpreting the results : HLA markers in the blood can help a doctor diagnose conditions that have an association with RA, such as ankylosing spondylitis and reactive arthritis.

What it tests : As with the uric acid test below, doctors use this test to rule out other conditions that are similar to RA.

This test detects the presence of antibodies that indicate Lyme disease. Interpreting the results : The presence of Lyme serology immune factors may signify that a person has Lyme disease rather than RA.

What it tests : This test measures the level of RF, which acts as an antibody against gamma globulins in the blood. However, doctors cannot conclude this from an RF test alone as several other conditions can increase the amount of RF in the body, including gout.

Similarly, a negative RF test result is insufficient evidence to confirm that a person does not have RA.

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Thrombocytosis in people with RA typically requires no treatment and will usually improve once the underlying inflammation is controlled.

The medication options include those that directly reduce inflammation and others that temper the autoimmune response.

Effort should also be made to quit smoking , exercise regularly , and lose excess weight , all of which can reduce inflammation and keep your RA symptoms under control.

Immune thrombocytopenia also tends to improve once the autoimmune response is brought under control.

Corticosteroids like prednisone may be used to support therapy by directly reducing inflammation. NSAIDs may also be prescribed but are generally avoided in people with low platelet counts due to increased risk of bleeding.

If your platelet count doesn't recover with treatment or is especially severe, your doctor may recommend intravenous immunoglobulin IVIG. Immunoglobulin is another type of antibody that your body normally makes to fight off infections.

With IVIG, immunoglobulin purified from the blood of healthy donors is delivered through an IV drip, usually for several hours a day for one to five days.

The advantage of IVIG is that it can raise your platelet count quickly, albeit temporarily. If your RA medications are causing a drop in your platelet count, your doctor may recommend a reduction in your dose.

The drugs most commonly associated with this are:. If the symptoms are especially severe or platelet levels fail to recover with a dose reduction, your doctor may stop treatment and switch you to another drug.

One of the more effective alternatives is the biologic drug Rituxan rituximab , which tempers the immune response by targeting B-cells , the very cells that destroy platelets in the autoimmune assault.

Dealing with chronic inflammation? An anti-inflammatory diet can help. Our free recipe guide shows you the best foods to fight inflammation.

Get yours today! Cleveland Clinic. Updated October 25, National Organization for Rare Disorders. Immune thrombocytopenia.

Updated May 30, Thrombocythemia and thrombocytosis. Factors associated with myelosuppression related to low-dose methotrexate therapy for inflammatory rheumatic diseases.

PLoS One. Food and Drug Administration. Methotrexate tablets, USP. Updated March Risk of incident cardiovascular events in patients with rheumatoid arthritis: a meta-analysis of observational studies.

Ann Rheum Dis. Updated Thrombocytosis: Management and treatment. Centers for Disease Control and Prevention.

Rheumatoid arthritis RA. Updated January 6, Izak M, Bussel JB. Management of thrombocytopenia. FPrime Rep. Published Jun 2. Table of Contents View All.

Understanding Platelet Function Disorders. Causes and Treatment of Myelosuppression. Complications of Rheumatoid Arthritis.

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